Monday, March 12, 2007

Mironov: Vacanti Mouse

From: Vladimir Mironov
Date: Mon, 12 Mar 2007 09:53:44 -0500

Vacanti mouse (some people claim that it is a second most famous mice after Mickie-Mouse) was done from biodegradable polymer seeded with cells and it somehow ( probably as result of post-transplanatational polymer biodegradation and tissue remodeling and contraction) could not maintain ear shape after implantation in vivo. No any successful clinical translation after 10 years... We together with our Chinese colleages from Tsinghua University, Beijing, China are using non-biodegradable FDA approved polyurethane and results are much better. I mean we do not see any change in ear shape during several months after implantation. Cosmetic effect is obvious. Is it an art (bio-sculpture) or not? It is up to professional artists to judge.If we can define art as something whhat could be placed in museum then it is an art. I saw transgenic obese mice in San Jose science museum...See in attachment correspondent slide of printed ear prostheses implanted into athymic rat.

Vladimir Mironov

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